Description

(R)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-value chiral ligand and catalyst precursor essential for asymmetric synthesis. Its significance lies in its ability to induce high enantioselectivity in critical organic transformations, enabling the production of optically pure intermediates. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing advanced active ingredients.

Application

• Asymmetric Catalysis: As a key ligand for transition metals (e.g., Rh, Ir, Ru) in enantioselective hydrogenation and C-C bond-forming reactions.
• Pharmaceutical Intermediates: Synthesis of chiral active pharmaceutical ingredients (APIs) for drugs targeting central nervous system, cardiovascular, and metabolic diseases.
• Agrochemical Synthesis: Production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Preparation of specialty chemicals, flavors, and fragrances requiring high optical purity.
• Academic & Industrial R&D: A versatile tool for method development and exploring new asymmetric synthetic pathways in chemistry research.
• Material Science: Potential use in the synthesis of chiral polymers and advanced organic materials with specific optical properties.

Basic Information

Product Name	(R)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1435948-37-0
Molecular Formula	C41H40O2
Molecular Weight	564.76 g/mol
Synonyms	(R)-SpiroBIAN Ligand; (R)-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobiindane-7,7'-diol; (R)-Spirobiindane Diol Ligand; (R)-Me4-SpiroBIAN; (R)-2,2',3,3'-Tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol, 6,6'-bis(2,4,6-trimethylphenyl)-, (R)-; (R)-H8-SpiroBIAN-(3,5-Me2-Ph)2; (R)-Spiro Diol Ligand; Asymmetric Spiro Diol Catalyst
EINECS	Contact for details

Quality Control

Our (R)-2,2',3,3'-Tetrahydro-6,6'-Bis(2,4,6-Trimethylphenyl)-1,1'-Spirobi[1H-Indene]-7,7'-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for asymmetric synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect catalytic performance. For long-term storage, consider using an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.