Description

tert-Butyl 7-Formyl-2-azaspiro[3.5]nonane-2-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and formyl-functionalized structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to introduce complex molecular architectures into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Building Block: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways due to its reactive aldehyde group.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for constructing nitrogen-containing spirocyclic compounds found in agrochemicals and specialty materials.

Basic Information

Product Name	tert-Butyl 7-Formyl-2-azaspiro[3.5]nonane-2-carboxylate
CAS No.	1434142-21-8
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	2-Azaspiro[3.5]nonane-2-carboxylic acid, 7-formyl-, 1,1-dimethylethyl ester; 7-Formyl-2-azaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-formyl-2-azaspiro[3.5]nonane-2-carboxylate; Boc-2-aza-7-formylspiro[3.5]nonane; 1,1-Dimethylethyl 7-formyl-2-azaspiro[3.5]nonane-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Formyl-2-azaspiro[3.5]nonane-2-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is easily oxidized (store under inert atmosphere) and is light-sensitive. Keep container tightly sealed under an inert atmosphere (nitrogen or argon) to maintain stability and prevent degradation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.