Description

tert-Butyl 6-(Hydroxymethyl)-1-Azaspiro[3.3]Heptane-1-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for constructing complex molecular architectures. It is primarily sought after by pharmaceutical companies and research institutions engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly those targeting the central nervous system.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker component due to its rigid spirocyclic structure and functional handles.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized compounds for clients.
• Library Synthesis: Enables the generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	tert-Butyl 6-(Hydroxymethyl)-1-Azaspiro[3.3]Heptane-1-Carboxylate
CAS No.	1434142-15-0
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	1-Boc-6-(hydroxymethyl)-1-azaspiro[3.3]heptane; 1-(tert-Butoxycarbonyl)-6-(hydroxymethyl)-1-azaspiro[3.3]heptane; 6-(Hydroxymethyl)-1-azaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester; tert-Butyl 6-(hydroxymethyl)-1-azaspiro[3.3]heptane-1-carboxylate; 1-Azaspiro[3.3]heptane-1-carboxylic acid, 6-(hydroxymethyl)-, 1,1-dimethylethyl ester; Boc-1-Azaspiro[3.3]heptane-6-methanol
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(Hydroxymethyl)-1-Azaspiro[3.3]Heptane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.