Description

tert-Butyl 9-Oxo-2-Azaspiro[5.5]Undecane-2-Carboxylate is a high-value, protected spirocyclic lactam building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel pharmaceutical candidates, particularly in the areas of central nervous system (CNS) and metabolic disease research. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex spirocyclic scaffolds found in bioactive molecules targeting G-protein-coupled receptors (GPCRs) and enzymes.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: The spirocyclic lactam core is a privileged structure in the design of inhibitors for various protease targets.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 9-Oxo-2-Azaspiro[5.5]Undecane-2-Carboxylate
CAS No.	1434142-14-9
Molecular Formula	C15H25NO3
Molecular Weight	267.36 g/mol
Synonyms	2-[(1,1-Dimethylethoxy)carbonyl]-2-aza-9-oxaspiro[5.5]undecane; 2-tert-Butoxycarbonyl-2-aza-9-oxaspiro[5.5]undecane; 9-Oxo-2-azaspiro[5.5]undecane-2-carboxylic acid tert-butyl ester; Boc-2-aza-9-oxaspiro[5.5]undecane; tert-Butyl 9-oxo-2-azaspiro[5.5]undecane-2-carboxylate; 2-Azaspiro[5.5]undecane-2-carboxylic acid, 9-oxo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 9-Oxo-2-Azaspiro[5.5]Undecane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.