Description

tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[3.5]Nonane-2-Carboxylate is a high-value, multifunctional spirocyclic building block essential for modern organic synthesis. This compound matters because its unique azaspiro[3.5]nonane core and protected functional groups make it a versatile intermediate for constructing complex molecular architectures with precise stereochemistry. Pharmaceutical and agrochemical R&D teams need it for developing new active ingredients, particularly in the areas of central nervous system (CNS) therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides with specific modes of action.
• Chemical Biology & Proteomics: Serves as a scaffold for designing molecular probes and activity-based protein profiling (ABPP) reagents.
• Ligand & Catalyst Development: Employed in the creation of novel chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics & Macrocyclic Compounds: The spirocyclic structure is integral for mimicking peptide secondary structures and constraining conformational flexibility in bioactive molecules.
• Academic & Contract Research: A critical reagent for methodological development in synthetic organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[3.5]Nonane-2-Carboxylate
CAS No.	1434141-69-1
Molecular Formula	C14H25NO3
Molecular Weight	255.35 g/mol
Synonyms	2-Azaspiro[3.5]nonane-2-carboxylic acid, 7-(hydroxymethyl)-, 1,1-dimethylethyl ester; 7-(Hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate; 2-tert-Butoxycarbonyl-7-(hydroxymethyl)-2-azaspiro[3.5]nonane; Boc-7-(hydroxymethyl)-2-azaspiro[3.5]nonane; (7-(Hydroxymethyl)-2-azaspiro[3.5]nonan-2-yl)carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-(Hydroxymethyl)-2-Azaspiro[3.5]Nonane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.