Description

Methyl 5,5-Difluoropiperidine-2-Carboxylate Hcl CAS NO 1434141-66-8 is a high-purity, fluorinated piperidine derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the difluoropiperidine moiety, a key structural feature that can enhance the metabolic stability, lipophilicity, and binding affinity of target molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoropiperidine structure can contribute to improved biological activity and environmental profile.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing enzyme inhibitors, receptor ligands, and molecular probes used in biochemical assays and target identification.
• Material Science Precursor: Potential use in the synthesis of specialty polymers, liquid crystals, or advanced materials requiring fluorinated heterocyclic components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in multi-step custom synthesis projects for clients.

Basic Information

Product Name	Methyl 5,5-Difluoropiperidine-2-Carboxylate Hcl
CAS No.	1434141-66-8
Molecular Formula	C7H12F2NO2 • HCl
Molecular Weight	227.63 g/mol (Free base: 191.17 g/mol)
Synonyms	Methyl 5,5-difluoropiperidine-2-carboxylate hydrochloride; 5,5-Difluoropiperidine-2-carboxylic acid methyl ester hydrochloride; 2-Piperidinecarboxylic acid, 5,5-difluoro-, methyl ester, hydrochloride; Methyl 5,5-difluoro-2-piperidinecarboxylate HCl; 1434141-66-8; Methyl 5,5-difluoropiperidine-2-carboxylate HCl salt
EINECS	Contact for details

Quality Control

Our Methyl 5,5-Difluoropiperidine-2-Carboxylate Hcl is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards in research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.