Description

2-Methanesulfonyl-2,6-Diazaspiro[3.3]Heptane is a high-value, spirocyclic building block featuring a diazaspiro[3.3]heptane core functionalized with a methanesulfonyl group. This compound is a critical intermediate in modern pharmaceutical discovery, particularly valued for its three-dimensional structure and polar properties that can improve drug-like characteristics. It is primarily utilized by medicinal chemists and process development scientists in the research and synthesis of novel therapeutic agents, especially within CNS and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of small molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degraders.
• CNS Drug Discovery: Employed in the development of compounds intended to cross the blood-brain barrier due to its favorable physicochemical profile.
• Chemical Biology Probes: Utilized in the creation of tool compounds for target validation and mechanistic studies.
• Process Chemistry & Scale-up: Sourced for route scouting and the development of robust, scalable synthetic processes for Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	2-Methanesulfonyl-2,6-Diazaspiro[3.3]Heptane
CAS No.	1433176-83-0
Molecular Formula	C7H14N2O2S
Molecular Weight	190.26 g/mol
Synonyms	2-(Methylsulfonyl)-2,6-diazaspiro[3.3]heptane; 2,6-Diazaspiro[3.3]heptane, 2-(methylsulfonyl)-; Methanesulfonyl-2,6-diazaspiro[3.3]heptane; 2-Methanesulfonyl-2,6-diaza-spiro[3.3]heptane; 2-(Methanesulfonyl)-2,6-diazaspiro[3.3]heptane; 2,6-Diazaspiro[3.3]heptane-2-methanesulfonate; Spirocyclic Sulfonamide Building Block
EINECS	Contact for details

Quality Control

Our 2-Methanesulfonyl-2,6-Diazaspiro[3.3]Heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.