Description

2-[2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetic Acid is a high-value, multi-functional chemical building block featuring both a carboxylic acid and a protected boronic ester functional group. This compound is essential for facilitating complex cross-coupling reactions, particularly in the synthesis of advanced pharmaceutical intermediates and organic electronic materials. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to construct novel molecular architectures with precision.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures, a cornerstone in modern medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), especially those requiring fluorinated biphenyl or phenylacetic acid motifs.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and insecticides that benefit from the stability of the pinacol boronate group.
• Material Science & OLED Development: Acts as a precursor for creating organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags due to its orthogonal reactivity for bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated boronic acid derivatives.

Basic Information

Product Name	2-[2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetic Acid
CAS No.	1431546-21-2
Molecular Formula	C14H18BFO4
Molecular Weight	280.10 g/mol
Synonyms	2-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid; [2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetic acid; 2-Fluoro-5-(pinacolboryl)phenylacetic acid; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzeneacetic acid; Pinacol [2-fluoro-5-(carboxymethyl)phenyl]boronate; CAS 1431546-21-2
EINECS	Contact for details

Quality Control

Our production of 2-[2-Fluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.