Description

Benzyl (3,3-Difluoro-2-Hydroxypropyl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated hydroxypropyl carbamate structure. This compound is of significant value in modern medicinal chemistry for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting challenging disease pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of fluorinated therapeutics, proteolysis-targeting chimeras (PROTACs), and other sophisticated small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated active pharmaceutical ingredients (APIs).
• PROTACs Development: Used in the construction of proteolysis-targeting chimeras for targeted protein degradation therapies.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and cellular pathways.
• Agrochemical Intermediates: Potential use in the synthesis of advanced, fluorinated agrochemicals for crop protection.

Basic Information

Product Name	Benzyl (3,3-Difluoro-2-Hydroxypropyl)Carbamate
CAS No.	1429913-43-8
Molecular Formula	C11H13F2NO3
Molecular Weight	245.22 g/mol
Synonyms	Carbamic acid, N-(3,3-difluoro-2-hydroxypropyl)-, phenylmethyl ester; Benzyl N-(3,3-difluoro-2-hydroxypropyl)carbamate; (3,3-Difluoro-2-hydroxypropyl)carbamic acid benzyl ester; N-Benzyloxycarbonyl-3,3-difluoro-2-hydroxypropylamine; Z-3,3-Difluoro-2-hydroxypropylamine; Cbz-3,3-difluoro-2-hydroxypropylamine; N-Cbz-3,3-difluoro-2-hydroxypropylamine
EINECS	Contact for details

Quality Control

Our Benzyl (3,3-Difluoro-2-Hydroxypropyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.