Description

1',3'-Dihydrospirocyclopropane-1,2'-Pyrazolo[3,2-B][1,3]Oxazine-6'-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Oncology Drug Discovery: Employed in the synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Development: Utilized as a building block for novel neuroactive compounds targeting various receptors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1',3'-Dihydrospirocyclopropane-1,2'-Pyrazolo[3,2-B][1,3]Oxazine-6'-Carboxylic Acid
CAS No.	1428234-37-0
Molecular Formula	C9H9N3O3
Molecular Weight	207.19 g/mol
Synonyms	1',3'-Dihydrospiro[cyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine]-6'-carboxylic acid; Spiro[cyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine]-6'-carboxylic acid, 1',3'-dihydro-; 1428234-37-0; Pyrazolo-oxazine carboxylic acid spirocyclopropane derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity, related substances, and residual solvents are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.