Description

1',3'-Dihydrospirocyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine-5'-carboxylic acid is a high-value, complex heterocyclic compound featuring a unique spirocyclic and fused ring system. This sophisticated molecular architecture makes it a critical advanced pharmaceutical intermediate and a versatile scaffold in medicinal chemistry research. It is primarily sought after by R&D and process development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Medicinal Chemistry Research: Used as a privileged scaffold for constructing compound libraries in high-throughput screening (HTS) campaigns to identify new lead molecules.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and kilogram-scale production for clinical trial material (CTM) and commercial API manufacturing.
• Chemical Biology Probes: Utilized to develop specialized molecular probes for studying enzyme function or protein-ligand interactions within biological systems.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	1',3'-Dihydrospirocyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine-5'-carboxylic acid
CAS No.	1428234-33-6
Molecular Formula	C11H11N3O3
Molecular Weight	233.22 g/mol
Synonyms	1',3'-Dihydrospiro[cyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine]-5'-carboxylic acid; Spiro[cyclopropane-1,2'-pyrazolo[3,2-b][1,3]oxazine]-5'-carboxylic acid, 1',3'-dihydro-; 1428234-33-6; 1,3-Dihydrospiro(cyclopropane-1,2'-pyrazolo(3,2-b)(1,3)oxazine)-5'-carboxylic acid; Pyrazolo[3,2-b][1,3]oxazine-5'-carboxylic acid, 1',3'-dihydrospiro[cyclopropane-1,2']-
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.