Description

(3S,5S)-Atorvastatin (Sodium Salt) CAS NO 1428118-38-0 is the high-purity, stereochemically defined sodium salt of the active pharmaceutical ingredient atorvastatin. This specific enantiomer is critical for ensuring optimal biological activity and minimizing off-target effects in pharmaceutical formulations. It is an essential advanced intermediate for research and development laboratories, as well as for manufacturers producing high-grade active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Active Ingredient (API) Synthesis: Serves as a key chiral intermediate in the production of atorvastatin calcium, a leading cholesterol-lowering drug.
• Reference Standard & Analytical Testing: Used as a high-purity standard in HPLC, LC-MS, and other analytical methods for quality control and method development.
• Metabolite & Impurity Studies: Employed in pharmacokinetic research to study metabolic pathways and identify related substances.
• Process Chemistry & Route Scouting: Utilized in the development and optimization of synthetic pathways for statin-based pharmaceuticals.
• Formulation Development: Acts as a model compound for developing stable salt forms and evaluating excipient compatibility in pre-formulation studies.
• Regulatory Submissions: Provides the necessary characterized material for regulatory filings (e.g., DMF, CMC sections) requiring a defined stereoisomer.

Basic Information

Product Name	(3S,5S)-Atorvastatin (Sodium Salt)
CAS No.	1428118-38-0
Molecular Formula	C33H34FN2NaO5
Molecular Weight	580.63 g/mol
Synonyms	(3S,5S)-Atorvastatin Sodium; Sodium (3S,5S)-Atorvastatin; Atorvastatin (3S,5S) Sodium Salt; (3R,5R)-Atorvastatin Sodium Salt (enantiomer); [R-(R*,R*)]-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, monosodium salt; Lipitor Intermediate; CI-981 Sodium Salt
EINECS	Contact for details

Quality Control

Our (3S,5S)-Atorvastatin Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and API synthesis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (3S,5S)-isomer
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.