Description

Methyl 3,4-Difluoro-5-(Trifluoromethyl)Benzoate is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring multiple fluorine atoms and a methyl ester group, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced potency and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the difluoro and trifluoromethyl groups improve biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and stability.
• Polymer Modification: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for constructing complex, multi-fluorinated aromatic systems.

Basic Information

Product Name	Methyl 3,4-Difluoro-5-(Trifluoromethyl)Benzoate
CAS No.	1427460-23-8
Molecular Formula	C9H5F5O2
Molecular Weight	240.13 g/mol
Synonyms	3,4-Difluoro-5-(trifluoromethyl)benzoic acid methyl ester; Methyl 3,4-difluoro-5-(trifluoromethyl)benzoate; Benzoic acid, 3,4-difluoro-5-(trifluoromethyl)-, methyl ester; Methyl 3,4-difluoro-α,α,α-trifluoro-m-toluate
EINECS	Contact for details

Quality Control

Our production of Methyl 3,4-Difluoro-5-(Trifluoromethyl)Benzoate adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is fully characterized and tested using advanced analytical techniques including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.