Description

4-Amino-2-Chloro-5-Fluoro-Benzoic Acid Methyl Ester is a high-purity, multi-functional chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its versatile molecular scaffold, which incorporates key functional groups—amine, chloro, fluoro, and ester—enabling precise modifications for complex molecule construction. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries, serving as a critical building block for active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the 2-chloro-5-fluoro-aniline moiety into more complex structures.
• Dye & Pigment Intermediate: Utilized in the production of specialized, high-performance fluorinated dyes and pigments for industrial applications.
• Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in academic and industrial laboratories for exploring new chemical entities.

Basic Information

Item	Details
Product Name	4-Amino-2-Chloro-5-Fluoro-Benzoic Acid Methyl Ester
CAS No.	1427413-83-9
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	Methyl 4-Amino-2-Chloro-5-Fluorobenzoate; 2-Chloro-5-Fluoro-4-Aminobenzoic Acid Methyl Ester; Benzoic acid, 4-amino-2-chloro-5-fluoro-, methyl ester; Methyl 4-Amino-2-Chloro-5-Fluorobenzoate; 4-Amino-2-Chloro-5-Fluorobenzoic Acid Methyl Ester; 2-Chloro-4-Amino-5-Fluorobenzoic Acid Methyl Ester; Methyl 2-Chloro-5-Fluoro-4-Aminobenzoate
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Chloro-5-Fluoro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and identity confirmation. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical pharmaceutical and agrochemical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the primary container to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.