Description

(S)-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is a high-value, chiral spirocyclic building block of significant interest in modern pharmaceutical research and development. Its unique constrained spirocyclic structure, featuring a nitrogen atom in the azetidine ring, makes it a privileged scaffold for designing novel bioactive molecules, particularly in medicinal chemistry. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of potential drug candidates, including protease inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a constrained scaffold for structure-activity relationship (SAR) studies and library synthesis to explore new chemical space.
• Protease Inhibitor Development: Used in the design and construction of molecules aimed at inhibiting specific proteases, a common target class in drug discovery.
• Asymmetric Synthesis: Employed as a chiral starting material or auxiliary in stereoselective synthesis to introduce complex three-dimensional architecture.
• Bioconjugation & Probe Synthesis: The carboxylic acid functionality allows for coupling to other molecules, useful in creating chemical probes for biological target identification.

Basic Information

Product Name	(S)-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid
CAS No.	1427203-49-3
Molecular Formula	C7H11NO2
Molecular Weight	141.17 g/mol
Synonyms	(7S)-5-Azaspiro[2.4]heptane-7-carboxylic acid; (S)-5-Azaspiro[2.4]heptane-7-carboxylic acid; (S)-5-Aza-spiro[2.4]heptane-7-carboxylic acid; (S)-Azetidine-2-spiro-1-cyclopropane-2-carboxylic acid; (S)-1-Azaspiro[2.4]heptane-7-carboxylic acid (tautomer); (S)-Spiro[azetidine-2,1'-cyclopropane]-2-carboxylic acid; Azetidine-2-spiro-1-cyclopropane-2-carboxylic acid, (S)-; (S)-Azetidine-2-spiro-1-cyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is manufactured under strict quality control protocols to ensure high chemical and chiral purity, critical for sensitive pharmaceutical applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.