Description

5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of new drug candidates, especially those incorporating constrained spirocyclic motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in targeted protein degradation therapeutics.
• Chemical Biology Probes: Employed in the synthesis of specialized molecules for studying biological pathways and target engagement.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) settings for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid
CAS No.	1427195-37-6
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	7-Carboxy-5-azaspiro[2.4]heptane; 5-Azaspiro[2.4]heptane-7-carboxylic acid; 1-Azaspiro[2.4]heptane-7-carboxylic acid (tautomer); 7-Azaspiro[2.4]heptane-1-carboxylic acid (alternative numbering); Azaspiroheptane carboxylic acid; Spiro[cyclopropane-1,2'-pyrrolidine]-5'-carboxylic acid; 2-Azabicyclo[2.1.1]hexane-1-carboxylic acid (bridged analog); 5-Aza-spiro[2.4]heptane-7-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Aza-Spiro[2.4]Heptane-7-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.