Description

Boc-Oxyma Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-Cyanoacetate is a high-purity, specialized reagent used as an efficient coupling additive in peptide synthesis. It matters because it offers a superior, safer alternative to traditional reagents like HOBt, minimizing the risk of exothermic reactions and improving coupling yields, particularly for challenging sequences. This product is essential for pharmaceutical R&D, biotech companies, and CROs engaged in the development of peptide-based therapeutics and APIs.

Application

• As a key coupling additive in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis.
• For the synthesis of complex and long-chain peptides, including therapeutic peptides and peptidomimetics.
• In the manufacturing of Active Pharmaceutical Ingredients (APIs) for peptide drugs.
• Used alongside carbodiimide reagents (e.g., DIC, EDC) to suppress racemization and enhance coupling efficiency.
• As a critical reagent in research and development for novel peptide discovery.
• In the production of custom peptides for diagnostic and research applications.

Basic Information

Product Name	Boc-Oxyma Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-Cyanoacetate
CAS No.	1426821-11-5
Molecular Formula	C₁₁H₁₆N₂O₆
Molecular Weight	272.26 g/mol
Synonyms	Boc-Oxyma; Ethyl (tert-Butoxycarbonyloxyimino)cyanoacetate; (Boc-O)Oxyma; 2-[(tert-Butoxycarbonyl)oxyimino]-2-cyanoacetic Acid Ethyl Ester; Ethyl 2-((tert-Butoxycarbonyl)oxyimino)-2-cyanoacetate; Oxyma-Boc; Boc-Oxyma Pure; Coupling Additive Boc-Oxyma
EINECS	Contact for details

Quality Control

Our Boc-Oxyma is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.