Description

Si-Tamra-6-Cooh is a high-purity, functionalized fluorescent dye derivative, specifically a carboxy-terminated tetramethylrhodamine (TAMRA) silane reagent. This compound is engineered for covalent conjugation to biomolecules and surfaces, offering a stable, bright orange-red fluorescence signal. It is an essential tool for researchers and manufacturers in the life sciences and diagnostics sectors who require reliable, site-specific labeling for applications such as fluorescence microscopy, flow cytometry, and in-situ hybridization.

Application

• Bioconjugation & Probe Synthesis: Primary reagent for labeling antibodies, peptides, oligonucleotides, and proteins with a bright, photostable TAMRA fluorophore.
• Diagnostic Assay Development: Used in the manufacture of fluorescent probes and detection reagents for clinical diagnostics, including immunoassays and nucleic acid tests.
• Cell & Tissue Imaging: Enables the preparation of fluorescent conjugates for high-resolution fluorescence microscopy and histology studies.
• Flow Cytometry: Serves as a key component in creating fluorescent markers for cell sorting and analysis.
• Surface Functionalization: The silane and carboxylic acid groups allow for the covalent attachment of fluorescent labels to glass, silicon, and other oxide surfaces for biosensor and microarray fabrication.
• Drug Delivery & Targeting Research: Utilized to track and visualize drug carriers, nanoparticles, and targeting moieties in preclinical research.

Basic Information

Product Name	Si-Tamra-6-Cooh
CAS No.	1426090-03-0
Molecular Formula	C41H47N3O8Si
Molecular Weight	737.92 g/mol
Synonyms	5(6)-Carboxy-TAMRA, SE; 5(6)-Carboxytetramethylrhodamine, succinimidyl ester, silicon derivative; TAMRA-6-acid, SE silane; 6-Carboxy-TAMRA, N-hydroxysuccinimide ester silane; Tetramethylrhodamine-6-isomer carboxylic acid NHS ester silane; Fluorescent silane labeling reagent; TAMRA NHS ester silane; Rhodamine-based silane coupling agent
EINECS	Contact for details

Quality Control

Every batch of Si-Tamra-6-Cooh is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and consistent performance through validated methods including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store in a freezer.

Specification

Item	Specification
Appearance	Orange to red solid or powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Isomer Content (HPLC)	≥ 90.0% (5- or 6-isomer)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.