Description

Gusacitinib is a potent and selective Janus kinase (JAK) and spleen tyrosine kinase (SYK) dual inhibitor, representing a significant advancement in targeted immunomodulatory therapy. Its primary value lies in its ability to simultaneously modulate multiple inflammatory signaling pathways, offering a promising mechanism for treating complex autoimmune and inflammatory disorders. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical R&D, preclinical studies, and the formulation of novel therapeutics targeting conditions such as rheumatoid arthritis, psoriasis, and other immune-mediated diseases.

Application

• Pharmaceutical Research & Development: Core material for investigating the efficacy of JAK/SYK dual inhibition in new drug candidates.
• Preclinical & Clinical Studies: Used in formulation development for animal models and human clinical trials targeting autoimmune conditions.
• Therapeutic Target - Rheumatoid Arthritis (RA): Key API for developing oral therapies designed to modulate the inflammatory response in RA.
• Therapeutic Target - Psoriasis & Psoriatic Arthritis: Employed in research for topical or systemic treatments aimed at skin and joint inflammation.
• Immunology Research Tools: Serves as a critical reference standard and biochemical tool for studying JAK-STAT and SYK signaling pathways in vitro.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and GMP production of finished dosage forms.

Basic Information

Product Name	Gusacitinib
CAS No.	1425381-60-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	ASN-002; (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide; UNII-8JQ4HZP6VY; 8JQ4HZP6VY
EINECS	Contact for details

Quality Control

Our Gusacitinib is manufactured under strict quality systems to ensure it meets the high standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can support development activities requiring material suitable for preclinical and clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.