Description

6-Fluoro-2-Azaspiro[3.3]heptane HCl is a high-value, synthetically challenging spirocyclic building block with a constrained, three-dimensional structure. This compound is critical for medicinal chemistry research, enabling the exploration of novel bioactive molecules with improved metabolic stability and target selectivity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, particularly in the areas of central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in fragment-based drug discovery and lead optimization to modulate physicochemical properties like lipophilicity and conformational rigidity.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or component in the design of bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the creation of tool compounds for target validation and pathway analysis in biological systems.
• Agrochemical Research: Potential intermediate in the development of advanced crop protection agents with novel modes of action.
• Material Science: Exploration of its use as a monomer or additive for creating specialty polymers with unique properties.

Basic Information

Product Name	6-Fluoro-2-Azaspiro[3.3]heptane HCl
CAS No.	1423032-55-6
Molecular Formula	C6H11FN•HCl
Molecular Weight	151.62 g/mol (Free base: 115.16 g/mol)
Synonyms	6-Fluoro-2-azaspiro[3.3]heptane hydrochloride; 2-Azaspiro[3.3]heptane, 6-fluoro-, hydrochloride; 6-Fluoro-2-azaspiro[3.3]heptane HCl; 6-Fluoro-2-azaspiro[3.3]heptane hydrochloride salt; 6-Fluoro-2-azaspiro[3.3]heptane, HCl; 1423032-55-6; 6-Fluoro-2-azaspiro[3.3]heptane monohydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-Azaspiro[3.3]heptane HCl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.