Description

2-(2,2-Difluoroethoxy)Pyridine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a difluoroethoxy side chain and a nitrile group. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine substitution for enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoroethoxy moiety can influence biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in organometallic chemistry and catalysis.
• Material Science: Potential monomer or additive in the synthesis of specialty polymers and advanced materials with tailored properties.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a probe molecule in biochemical assays.

Basic Information

Product Name	2-(2,2-Difluoroethoxy)Pyridine-3-Carbonitrile
CAS No.	1423032-05-6
Molecular Formula	C8H6F2N2O
Molecular Weight	184.14 g/mol
Synonyms	3-Cyano-2-(2,2-difluoroethoxy)pyridine; 2-(2,2-Difluoroethoxy)-3-pyridinecarbonitrile; Pyridine-3-carbonitrile, 2-(2,2-difluoroethoxy)-; 2-(2,2-Difluoroethoxy)nicotinonitrile; 2-(Difluoroethoxy)-3-cyanopyridine; 3-Pyridinecarbonitrile, 2-(2,2-difluoroethoxy)-
EINECS	Contact for details

Quality Control

Our 2-(2,2-Difluoroethoxy)Pyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.