Description

Methyl2-Amino-2-(3,4-Difluorophenyl)Acetate Hydrochloride is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected, fluorinated phenylglycine scaffold essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated fluorine chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors and enzyme modulators.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the difluorophenyl moiety enhances metabolic stability and bioavailability.
• Peptidomimetics & Bioactive Molecule Construction: Integral for creating peptide analogs and other bioactive compounds that mimic natural substrates.
• Chemical Biology Probes: Serves as a building block for fluorinated probes used in studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chirality.
• Material Science Research: Potential precursor for specialty polymers or liquid crystals incorporating fluorinated aromatic units.

Basic Information

Product Name	Methyl2-Amino-2-(3,4-Difluorophenyl)Acetate Hydrochloride
CAS No.	1423024-63-8
Molecular Formula	C9H10F2NO2·HCl
Molecular Weight	239.64 (Free base) / 276.10 (HCl salt)
Synonyms	Methyl 2-Amino-2-(3,4-difluorophenyl)acetate hydrochloride; Methyl (3,4-Difluorophenyl)glycinate hydrochloride; 2-Amino-2-(3,4-difluorophenyl)acetic acid methyl ester hydrochloride; (3,4-Difluorophenyl)glycine methyl ester HCl; Methyl α-amino-3,4-difluorobenzeneacetate hydrochloride; DL-3,4-Difluorophenylglycine methyl ester hydrochloride; MFCD30132632
EINECS	Contact for details

Quality Control

Our production of Methyl2-Amino-2-(3,4-Difluorophenyl)Acetate Hydrochloride adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While typically supplied as a high-purity R&D grade, we can discuss compliance with specific pharmacopeial standards (e.g., ICH guidelines for impurities) for advanced development and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.