Description

((3S,5S,E)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethyl Sulfonamido)Pyrimidin-5-Yl)-3,5-Dihydroxyhept-6-Enoate)Calcium (Ii) is a high-purity, advanced pharmaceutical intermediate with a complex stereochemistry critical for modern drug synthesis. This compound matters as a key building block in the development of novel therapeutic agents, particularly in the statin and cholesterol-lowering drug class. It is essential for pharmaceutical R&D laboratories and manufacturers requiring precise, high-quality intermediates for the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a critical chiral building block in the synthesis of statin-class Active Pharmaceutical Ingredients (APIs).
• Research & Development: Serves as a key reference standard and starting material in medicinal chemistry for developing new HMG-CoA reductase inhibitors.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of cardiovascular drugs.
• Custom Synthesis: A foundational compound for the custom synthesis of novel analogs and derivatives for biological screening.
• Analytical Standard: Employed as a high-purity standard in HPLC, LC-MS, and NMR for method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	((3S,5S,E)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethyl Sulfonamido)Pyrimidin-5-Yl)-3,5-Dihydroxyhept-6-Enoate)Calcium (Ii)
CAS No.	1422515-55-6
Molecular Formula	C26H33CaFN3O7S
Molecular Weight	605.70 g/mol
Synonyms	Calcium (3S,5S,E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonamido)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate; Pitavastatin Calcium Intermediate; Livalo® Intermediate; NK-104 Intermediate; (3S,5S,E)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methylmethylsulfonamido)Pyrimidin-5-yl)-3,5-Dihydroxyhept-6-Enoic Acid Calcium Salt; Calcium Pitavastatin Key Intermediate; Itavastatin Calcium Intermediate
EINECS	Contact for details

Quality Control

Our ((3S,5S,E)-7-(4-(4-Fluorophenyl)-6-Isopropyl-2-(n-Methylmethyl Sulfonamido)Pyrimidin-5-Yl)-3,5-Dihydroxyhept-6-Enoate)Calcium (Ii) is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and stereochemical purity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (3S,5S,E isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.