Description

n-(Cyclopropylmethyl)Spiro[Indene-1,4'-Piperidine]-3-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic and piperidine-based molecular architecture. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. Pharmaceutical research and development organizations, as well as fine chemical manufacturers, need this precise intermediate to support their discovery pipelines and process development for new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its spirocyclic scaffold.
• API Synthesis: Employed in the scalable production of potential active pharmaceutical ingredients requiring its specific pharmacophore.
• Biochemical Tool Compound: May be utilized in preclinical studies as a reference standard or probe to investigate biological pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Used in university and institutional labs for advanced organic synthesis and pharmaceutical science projects.

Basic Information

Product Name	n-(Cyclopropylmethyl)Spiro[Indene-1,4'-Piperidine]-3-Carboxamide
CAS No.	1422136-64-8
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Spiro[indene-1,4'-piperidine]-3-carboxamide, N-(cyclopropylmethyl)-; 1'-(Cyclopropylmethyl)spiro[indene-1,4'-piperidine]-3-carboxamide; n-(Cyclopropylmethyl)-1'H-spiro[indene-1,4'-piperidine]-3-carboxamide; Spiro[indene-1,4'-piperidine]-3-carboxylic acid cyclopropylamide; CAS 1422136-64-8
EINECS	Contact for details

Quality Control

Our n-(Cyclopropylmethyl)Spiro[Indene-1,4'-Piperidine]-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.