Description

1-Phenyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 1421312-09-5. This compound is a critical building block in modern medicinal chemistry, valued for its unique fused heterocyclic structure that serves as a core scaffold for drug discovery. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a privileged scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Used in the research and synthesis of potential therapeutics for neurological and psychiatric disorders.
• Oncology Research: Employed as a building block for developing kinase inhibitors and other targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	1-Phenyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester
CAS No.	1421312-09-5
Molecular Formula	C19H23N3O2
Molecular Weight	325.41 g/mol
Synonyms	tert-Butyl 1-phenyl-1,5,6,7-tetrahydropyrazolo[4,3-b]pyridine-4-carboxylate; 1-Phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; 1-Phenyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; 1421312-09-5; Pyrazolopyridine tert-butyl ester intermediate
EINECS	Contact for details

Quality Control

Our production of 1-Phenyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality systems are designed to support cGMP requirements for pharmaceutical intermediates, ensuring traceability and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled with appropriate precautions for materials soluble in strong acid/organic solvent. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.