Description

2-Methyl-2,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyrazolopyridine heterocyclic structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D departments, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in novel drug development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates targeting various therapeutic areas.
• API Synthesis: Serves as a key building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing.
• Medicinal Chemistry R&D: Used extensively in research laboratories for structure-activity relationship (SAR) studies and lead optimization.
• CNS Drug Development: Particularly relevant in the synthesis of compounds designed to interact with neurological targets.
• Oncology Research: Employed in the development of potential kinase inhibitors and other anti-cancer agents.
• Contract Manufacturing: Supplied to CMOs and CDMOs for scale-up and cGMP production of clinical trial materials.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development.

Basic Information

Item	Details
Product Name	2-Methyl-2,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester
CAS No.	1421312-00-6
Molecular Formula	C13H19N3O2
Molecular Weight	249.31 g/mol
Synonyms	tert-Butyl 2-methyl-2,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridine-4-carboxylate; 2-Methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; 2-Methyl-2,4,5,6,7,8-hexahydropyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; Pyrazolopyridine tert-butyl ester intermediate; CAS 1421312-00-6
EINECS	Contact for details

Quality Control

Our 2-Methyl-2,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided for all shipments, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.