Description

1-Methyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrazolopyridine chemical class. This compound is a critical building block in modern medicinal chemistry, valued for its unique heterocyclic scaffold that enables the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Employed in the research and development of potential therapeutics for neurological disorders due to its privileged heterocyclic structure.
• Oncology Research: Utilized as a building block for creating potential kinase inhibitors and other targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-Methyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester
CAS No.	1421311-98-9
Molecular Formula	C13H19N3O2
Molecular Weight	249.31 g/mol
Synonyms	tert-Butyl 1-methyl-1,5,6,7-tetrahydro-4H-pyrazolo[4,3-b]pyridine-4-carboxylate; 1-Methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; 4-(tert-Butoxycarbonyl)-1-methyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridine; 1-Methyl-1,4,5,6,7,8-hexahydropyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester; Pyrazolo[4,3-b]pyridine-4-carboxylic acid, 1,5,6,7-tetrahydro-1-methyl-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Methyl-1,5,6,7-tetrahydro-pyrazolo[4,3-b]pyridine-4-carboxylic acid tert-butyl ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade requirements, with quality systems designed to meet the rigorous standards of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.