Description

7,7-Difluoro-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Ol Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorinated pyrazolopyridine scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other targeted therapeutics for oncology and central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drugs, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged heterocyclic structure.
• Oncology Drug Discovery: Serves as a core scaffold for compounds targeting specific cancer pathways.
• Chemical Biology Probes: Utilized in the design of tool compounds for studying enzyme function and cellular signaling.
• Process Chemistry & Scale-Up: Supplied for route scouting and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Research & Manufacturing (CRO/CMO): A reliable raw material for custom synthesis and development services.

Basic Information

Product Name	7,7-Difluoro-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Ol Hydrochloride
CAS No.	1421270-62-3
Molecular Formula	C7H8ClF2N3O
Molecular Weight	223.61 g/mol
Synonyms	7,7-Difluoro-1,4,5,6-tetrahydro-3H-pyrazolo[4,3-c]pyridin-3-one hydrochloride; 7,7-Difluoro-4,5,6,7-tetrahydro-3H-pyrazolo[4,3-c]pyridin-3-one HCl; 1421270-62-3; 3-Hydroxy-7,7-difluoro-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride; Difluorinated Pyrazolopyridinone HCl Salt
EINECS	Contact for details

Quality Control

Every batch of 7,7-Difluoro-4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridin-3-Ol Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting regulatory filings from preclinical to commercial stages. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.