Description

tert-Butyl 8-(Hydroxymethyl)-2-Azaspiro[4.5]Decane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and hydroxymethylated structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with enhanced pharmacological properties. It is primarily utilized by R&D and production teams in the pharmaceutical and biotechnology sectors for the development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or core component in the design of bifunctional molecules for targeted protein degradation.
• Medicinal Chemistry & Lead Optimization: Used to introduce conformational constraint and functional groups that improve drug-like properties such as solubility, metabolic stability, and target binding affinity.
• Contract Research & Manufacturing (CRMO): Supplied to custom synthesis organizations for scale-up and process development of client-specific compounds.
• Academic Research: Employed in university and institutional labs for studying spirocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 8-(Hydroxymethyl)-2-Azaspiro[4.5]Decane-2-Carboxylate
CAS No.	1420955-72-1
Molecular Formula	C15H27NO3
Molecular Weight	269.38 g/mol
Synonyms	2-Azaspiro[4.5]decane-2-carboxylic acid, 8-(hydroxymethyl)-, 1,1-dimethylethyl ester; 8-(Hydroxymethyl)-2-azaspiro[4.5]decane-2-carboxylic acid tert-butyl ester; tert-Butyl 8-(hydroxymethyl)-2-azaspiro[4.5]decane-2-carboxylate; 2-tert-Butoxycarbonyl-8-(hydroxymethyl)-2-azaspiro[4.5]decane; 8-Hydroxymethyl-2-N-Boc-2-azaspiro[4.5]decane; Boc-8-(hydroxymethyl)-2-azaspiro[4.5]decane; 2-Azaspiro[4.5]decane, 8-(hydroxymethyl)-, 2-(1,1-dimethylethyl) carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-(Hydroxymethyl)-2-Azaspiro[4.5]Decane-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.