Description

4-Aza-Spiro[2.4]Heptane-4-Carboxylic Acid tert-Butyl Ester is a sophisticated spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the central nervous system (CNS) and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly those with spirocyclic or constrained ring systems.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical space.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to introduce chirality and complex three-dimensionality into target molecules.
• Ligand and Catalyst Development: Potential precursor for novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Intermediate in the development of new, biologically active compounds for crop protection.

Basic Information

Product Name	4-Aza-Spiro[2.4]Heptane-4-Carboxylic Acid tert-Butyl Ester
CAS No.	1420294-82-1
Molecular Formula	C11H19NO2
Molecular Weight	197.27 g/mol
Synonyms	tert-Butyl 4-azaspiro[2.4]heptane-4-carboxylate; 4-Azaspiro[2.4]heptane-4-carboxylic acid, 1,1-dimethylethyl ester; 4-tert-Butoxycarbonyl-4-azaspiro[2.4]heptane; 4-Boc-4-azaspiro[2.4]heptane; 4-Aza-spiro[2.4]heptane-4-carboxylic acid tert-butyl ester; 4-N-Boc-4-azaspiro[2.4]heptane; 1,1-Dimethylethyl 4-azaspiro[2.4]heptane-4-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Aza-Spiro[2.4]Heptane-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.