Description

5-Cbz-5-Azaspiro[2.4]Heptane-1-Methanol is a high-value, nitrogen-containing spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, antiviral agents, and other therapeutic small molecules.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space due to its constrained spirocyclic structure.
• Process Chemistry & Scale-up: Employed in the development and optimization of synthetic routes for active pharmaceutical ingredients (APIs) at various scales, from laboratory to pilot plant.
• Agrochemical Synthesis: Acts as a building block for developing new crop protection agents and pesticides with novel modes of action.
• Ligand and Catalyst Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Academic Research: A valuable reagent for methodology development and exploring new reactions involving strained spirocyclic systems in university and institutional laboratories.

Basic Information

Product Name	5-Cbz-5-Azaspiro[2.4]Heptane-1-Methanol
CAS No.	1419101-25-9
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	1-(Hydroxymethyl)-5-[(phenylmethoxy)carbonyl]-5-azaspiro[2.4]heptane; 5-[(Benzyloxy)carbonyl]-5-azaspiro[2.4]heptane-1-methanol; 5-Cbz-5-azaspiro[2.4]heptane-1-methanol; 5-[(Phenylmethoxy)carbonyl]-5-azaspiro[2.4]heptane-1-methanol; 5-Azaspiro[2.4]heptane-1-methanol, 5-[(phenylmethoxy)carbonyl]-; Benzyl 1-(hydroxymethyl)-5-azaspiro[2.4]heptane-5-carboxylate; (1-Hydroxymethyl-5-azaspiro[2.4]hept-5-yl)-carbamic acid benzyl ester
EINECS	Contact for details

Quality Control

Our 5-Cbz-5-Azaspiro[2.4]Heptane-1-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring consistency and reliability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.