Description

Azide-Peg7-Tos is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a tosylate leaving group, separated by a heptaethylene glycol spacer. This compound is essential for creating stable, well-defined bioconjugates and functionalized materials through efficient click chemistry and nucleophilic substitution reactions. It is primarily needed by researchers and manufacturers in pharmaceutical development, bioconjugation, and materials science for constructing drug delivery systems, diagnostic probes, and advanced polymer architectures.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: The azide group enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkyne-modified biomolecules, while the tosylate allows for subsequent functionalization with amines or thiols.
• PEGylation of Therapeutic Agents: Serves as a versatile linker to attach PEG chains to drugs, peptides, or proteins, improving solubility, stability, and pharmacokinetic profiles.
• Polymer and Dendrimer Functionalization: Used as a building block to introduce click-reactive azide handles into polymer backbones or dendritic structures for further modular assembly.
• Surface Modification and Nanomaterial Labeling: Facilitates the covalent attachment of functional molecules to nanoparticles, quantum dots, or biosensor surfaces via the reactive tosylate and azide termini.
• Crosslinking Reagent: Acts as a heterobifunctional crosslinker to bridge two different molecules or materials through orthogonal chemical reactions.
• Synthesis of Prodrugs and Diagnostic Agents: Enables the construction of cleavable or non-cleavable linkers between targeting moieties and payloads in prodrugs or imaging contrast agents.

Basic Information

Item	Details
Product Name	Azide-Peg7-Tos
CAS No.	1418561-41-7
Molecular Formula	C26H45N3O10S
Molecular Weight	591.72 g/mol
Synonyms	Azido-PEG7-tosylate; 1-Azido-3,6,9,12,15,18,21-heptaoxatricosan-23-yl 4-methylbenzenesulfonate; Tosyl-PEG7-azide; N3-PEG7-OTs; PEG7 azide tosylate; Heptaethylene glycol azide tosylate; Azido-hepta(ethylene glycol) tosylate; Heterobifunctional PEG linker, Azide/Tosylate
EINECS	Contact for details

Quality Control

Our Azide-Peg7-Tos is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.