Description

Siponimod is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of advanced pharmaceutical formulations. It is primarily required by pharmaceutical research organizations and manufacturers engaged in the production of treatments for autoimmune and neurological conditions.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of prescription medications.
• Neurological Research: Key compound for preclinical and clinical studies targeting multiple sclerosis (MS) and related demyelinating diseases.
• Immunomodulatory Drug Development: Used in R&D for novel therapies that modulate the S1P receptor pathway to manage autoimmune responses.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical labs.
• Formulation Development: Utilized in the development of various dosage forms, including oral tablets.
• Process Chemistry & Scale-up: Employed in the optimization and scaling of synthetic routes for commercial manufacturing.

Basic Information

Product Name	Siponimod
CAS No.	1418144-65-6
Molecular Formula	C29H35FN2O2
Molecular Weight	462.60 g/mol
Synonyms	BAF312; 1-{4-[(1E)-1-({[4-cyclohexyl-3-(trifluoromethyl)phenyl]amino}carbonyl)ethenyl]-2-ethylbenzyl}azetidine-3-carboxylic acid; (E)-1-(4-(1-((4-Cyclohexyl-3-(trifluoromethyl)phenyl)carbamoyl)vinyl)-2-ethylbenzyl)azetidine-3-carboxylic acid; Mayzent (brand name)
EINECS	Contact for details

Quality Control

Our Siponimod is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) compliant with current regulatory expectations are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.