Description

3-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate characterized by its unique piperidine and trifluoromethylpyridine hybrid structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and fine chemical manufacturers seeking to incorporate its specific halogenated and fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.
• Chemical Biology: Useful as a probe or ligand in biochemical assays due to its specific molecular recognition properties.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	3-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1417793-54-4
Molecular Formula	C18H22ClF3N2O3
Molecular Weight	406.83 g/mol
Synonyms	tert-Butyl 3-[[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy]methyl]piperidine-1-carboxylate; 1-Boc-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)methyl)piperidine; 1-(tert-Butoxycarbonyl)-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)methyl)piperidine; 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yloxy)methyl)piperidine-1-carboxylic acid tert-butyl ester; CAS 1417793-54-4; BOC-protected piperidine-pyridine ether intermediate
EINECS	Contact for details

Quality Control

Our production of 3-(3-Chloro-5-Trifluoromethyl-Pyridin-2-Yloxymethyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.