Description

6-[(tert-Butoxy)Carbonyl]-6-Azaspiro[2.5]Octane-5-Carboxylic Acid is a high-value, protected amino acid derivative featuring a unique spirocyclic structure. This compound serves as a critical advanced pharmaceutical intermediate (API) for constructing complex molecular architectures in drug discovery and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within medicinal chemistry programs targeting central nervous system (CNS) disorders and other specialized applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and investigational new drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Peptidomimetics & Constrained Peptides: Its spirocyclic structure is valuable for introducing conformational constraints into peptide analogs to enhance stability and bioavailability.
• Chemical Biology Probes: Employed in the development of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	6-[(tert-Butoxy)Carbonyl]-6-Azaspiro[2.5]Octane-5-Carboxylic Acid
CAS No.	1417743-24-8
Molecular Formula	C₁₃H₂₁NO₄
Molecular Weight	255.31 g/mol
Synonyms	6-(tert-Butoxycarbonyl)-6-azaspiro[2.5]octane-5-carboxylic acid; 6-Boc-6-azaspiro[2.5]octane-5-carboxylic acid; 6-Azaspiro[2.5]octane-5-carboxylic acid, 6-[(1,1-dimethylethoxy)carbonyl]-; Boc-6-Azaspiro[2.5]octane-5-COOH; tert-Butyl 5-carboxy-6-azaspiro[2.5]octane-6-carboxylate; 6-N-Boc-6-azaspiro[2.5]octane-5-carboxylic acid; (5-Carboxy-6-azaspiro[2.5]octan-6-yl)-tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our 6-[(tert-Butoxy)Carbonyl]-6-Azaspiro[2.5]Octane-5-Carboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.