Description

trans-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a sterically hindered piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a key chiral building block for the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active drugs, protease inhibitors, and other therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained piperidine ring system.
• Asymmetric Synthesis: Serves as a precursor for chiral ligands, catalysts, or auxiliaries in stereoselective transformations.
• Agrochemical Development: Employed in the synthesis of novel pesticides and herbicides that require specific stereochemistry for activity.
• Peptidomimetics: The dicarboxylic acid ester moiety makes it valuable for constructing peptide analogs and conformationally restricted scaffolds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of targeted APIs under cGMP conditions.

Basic Information

Product Name	trans-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1417705-89-5
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-(tert-Butyl) 3-methyl (2R,6S)-6-methylpiperidine-1,3-dicarboxylate; (2R,6S)-1-tert-Butyl 3-methyl 6-methylpiperidine-1,3-dicarboxylate; trans-1-Boc-6-methyl-3-piperidinecarboxylic acid methyl ester; trans-6-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; 6-Methylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester, trans-; (2R,6S)-6-Methylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester
EINECS	Contact for details

Quality Control

Our trans-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure stereochemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and physical characteristics. Our quality commitment supports development from research to commercial scale under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.