Description

Spiro[Cyclopropane-1,3'-[3H]Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is a sophisticated spirocyclic organic compound featuring a fused pyrrolopyridine core, representing a valuable scaffold in modern synthetic chemistry. This compound is of significant interest for its role as a key intermediate in the research and development of novel pharmaceutical agents, particularly in kinase inhibitor programs. It is primarily sought after by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially in oncology and CNS therapeutic areas.
• Kinase Inhibitor Research: Serves as a core structural motif in the design and development of novel kinase inhibitors for targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization processes to enhance drug-like properties.
• Chemical Biology: Employed as a molecular probe to study biological pathways and protein-ligand interactions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized APIs (Active Pharmaceutical Ingredients) and advanced intermediates.
• Academic Research: Utilized in universities and research institutes for methodological development in heterocyclic and spirocyclic chemistry.

Basic Information

Product Name	Spiro[Cyclopropane-1,3'-[3H]Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One
CAS No.	1416438-78-2
Molecular Formula	C10H8N2O
Molecular Weight	172.18 g/mol
Synonyms	1'H-Spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-2'-one; Spiro(cyclopropane-1,3'-[3H]pyrrolo[2,3-b]pyridin)-2'(1'H)-one; 1416438-78-2; Spirocyclopropanepyrrolopyridinone; SC-2; Spirocyclic pyrrolopyridinone intermediate
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,3'-[3H]Pyrrolo[2,3-B]Pyridin]-2'(1'H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) are available for every batch, detailing all critical quality attributes. Our quality commitment aligns with the standards expected for non-GMP advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.