Description

Methyl 2-Amino-4-Hydroxy-4-Methylpentanoate CAS NO 1416438-05-5 is a high-purity, non-proteinogenic amino acid ester derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring both amino and hydroxyl functional groups on a branched carbon chain, makes it an invaluable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new therapeutic agents, including protease inhibitors and other bioactive molecules.
• Peptidomimetics & Bioactive Peptide Synthesis: Used to introduce constrained, branched-chain amino acid motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Chemical Biology & Proteomics Research: Utilized in the design and synthesis of activity-based probes, enzyme substrates, and other research tools.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialized agrochemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	Methyl 2-Amino-4-Hydroxy-4-Methylpentanoate
CAS No.	1416438-05-5
Molecular Formula	C8H17NO3
Molecular Weight	175.23 g/mol
Synonyms	Methyl 2-Amino-4-hydroxy-4-methylpentanoate; 2-Amino-4-hydroxy-4-methylpentanoic acid methyl ester; 4-Methyl-4-hydroxy-2-aminopentanoic acid methyl ester; Methyl 4-hydroxy-4-methyl-2-aminopentanoate; 2-Amino-4-hydroxy-4-methyl-valeric acid methyl ester; (2S)-2-Amino-4-hydroxy-4-methylpentanoic acid methyl ester (for specific enantiomer); 4-Hydroxy-4-methyl-2-aminopentanoic acid methyl ester; HMP Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-4-Hydroxy-4-Methylpentanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.