Description

n-Boc-3-[(Acetyloxy)Methyl]-2-Oxa-8-Azaspiro[4.5]Decane is a specialized spirocyclic building block featuring both Boc-protected amine and acetyl-protected hydroxyl functionalities. This compound matters as a critical intermediate in modern pharmaceutical research, enabling the efficient synthesis of complex molecules with precise stereochemistry. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing novel active pharmaceutical ingredients (APIs) and advanced drug candidates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: Potential precursor in the development of inhibitors for various enzymatic targets due to its spirocyclic and protected heteroatom structure.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and protein function.
• Library Synthesis for High-Throughput Screening: Enables the generation of diverse compound libraries for biological screening campaigns.

Basic Information

Product Name	n-Boc-3-[(Acetyloxy)Methyl]-2-Oxa-8-Azaspiro[4.5]Decane
CAS No.	1416372-24-1
Molecular Formula	C16H27NO5
Molecular Weight	313.39 g/mol
Synonyms	tert-Butyl 3-(acetoxymethyl)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-Boc-3-(acetoxymethyl)-2-oxa-8-azaspiro[4.5]decane; 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-[(acetyloxy)methyl]-, 1,1-dimethylethyl ester; 3-(Acetoxymethyl)-8-Boc-2-oxa-8-azaspiro[4.5]decane; 8-(tert-Butoxycarbonyl)-3-(acetoxymethyl)-2-oxa-8-azaspiro[4.5]decane; Boc-Protected Spirocyclic Amino Ester; 1416372-24-1
EINECS	Contact for details

Quality Control

Our n-Boc-3-[(Acetyloxy)Methyl]-2-Oxa-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements. We adhere to cGMP principles for pharmaceutical intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.