Description

4-(2-Oxa-6-Azaspiro[3.3]Hept-6-Yl)Benzenamine is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is valued for its role as a key building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with improved pharmacological profiles. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of innovative therapeutics, particularly in areas requiring complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for investigating biological pathways and target validation.
• Agrochemical Research: May be employed in the discovery of new active ingredients for crop protection, leveraging its heterocyclic structure.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	4-(2-Oxa-6-Azaspiro[3.3]Hept-6-Yl)Benzenamine
CAS No.	1416369-77-1
Molecular Formula	C12H14N2O
Molecular Weight	202.25 g/mol
Synonyms	4-(2-Oxa-6-azaspiro[3.3]heptan-6-yl)aniline; 6-(4-Aminophenyl)-2-oxa-6-azaspiro[3.3]heptane; Benzenamine, 4-(2-oxa-6-azaspiro[3.3]hept-6-yl)-; 4-(2-Oxa-6-azaspiro[3.3]heptan-6-yl)benzenamine; 4-(2-Oxa-6-azaspiro[3.3]hept-6-yl)phenylamine; 6-(4-Aminophenyl)-2-oxa-6-azaspiro[3.3]heptane; CAS 1416369-77-1
EINECS	Contact for details

Quality Control

Our 4-(2-Oxa-6-Azaspiro[3.3]Hept-6-Yl)Benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.