Description

Azide-PEG5-t-butyl ester is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a protected carboxylic acid. This compound is essential for creating stable, biocompatible conjugates in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted drug delivery systems, functionalized surfaces, and novel biomaterials.

Application

• Bioconjugation and Click Chemistry: The azide terminus enables efficient, copper-catalyzed or strain-promoted cycloaddition (click chemistry) with alkyne-modified biomolecules such as proteins, antibodies, or oligonucleotides.
• Drug Delivery System Development: Serves as a key linker for attaching targeting ligands or therapeutic payloads to PEGylated nanoparticles or polymer backbones, enhancing solubility and circulation time.
• Surface Functionalization: Used to modify materials (e.g., glass, gold, polymers) with azide groups for subsequent immobilization of biomolecules, creating biosensors or bioactive coatings.
• Proteomics Research: Acts as a reagent for chemical proteomics, enabling the labeling and enrichment of specific proteins or post-translational modifications for mass spectrometry analysis.
• Polymer and Hydrogel Synthesis: Incorporated as a crosslinking agent or functional monomer to introduce reactive azide handles into synthetic polymers or hydrogels for further modification.
• Diagnostic Reagent Preparation: Facilitates the development of diagnostic assays by linking detection molecules (e.g., fluorophores, enzymes) to antibodies or other capture agents.

Basic Information

Product Name	Azide-PEG5-t-butyl ester
CAS No.	1415800-41-7
Molecular Formula	C19H37N3O7
Molecular Weight	419.52 g/mol
Synonyms	1-Azido-3,6,9,12,15-pentaoxaoctadecan-18-oic acid tert-butyl ester; Azido-PEG5-t-butyl ester; tert-Butyl 17-azido-3,6,9,12,15-pentaoxaheptadecanoate; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester; Azido-Pentaethylene glycol-t-butyl ester; N3-PEG5-COOtBu; Azido-OEG5-t-butyl ester; PEG5-Azide-t-butyl ester
EINECS	Contact for details

Quality Control

Our Azide-PEG5-t-butyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. For long-term storage under inert atmosphere, keep the container sealed under nitrogen or argon. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.