Description

Bromo-Peg5-T-Butyl Ester is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal bromo group and a protected carboxylic acid. This bifunctional linker is essential for creating stable, hydrophilic spacers in bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for synthesizing antibody-drug conjugates (ADCs), peptide modifications, and functionalized polymers.

Application

• Bioconjugation Linker: A key intermediate for attaching cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides in ADC and diagnostic probe development.
• Polymer Functionalization: Serves as a versatile monomer or terminating agent for synthesizing PEG-based block copolymers, hydrogels, and smart materials with tailored properties.
• Prodrug Synthesis: Used to create solubilizing PEGylated prodrugs, where the t-butyl ester can be cleaved to release the active pharmaceutical ingredient (API).
• Surface Modification: Facilitates the PEGylation of nanoparticles, quantum dots, and other surfaces to improve biocompatibility, stability, and circulation time.
• Chemical Biology Tools: Employed in the synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker for coupling molecules containing thiol, amine, or other nucleophilic groups.

Basic Information

Product Name	Bromo-Peg5-T-Butyl Ester
CAS No.	1415800-38-2
Molecular Formula	C21H41BrO9
Molecular Weight	517.45 g/mol
Synonyms	1-Bromo-3,6,9,12,15-pentaoxaheptadecan-17-oic acid tert-butyl ester; 2-[2-[2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid tert-butyl ester; tert-Butyl 17-bromo-3,6,9,12,15-pentaoxaheptadecan-17-oate; Bromo-PEG5-t-butyl ester; Br-PEG5-OtBu; Bromo-PEG5-acid t-butyl ester; Bromo tetraethylene glycol monomethyl ether t-butyl ester derivative
EINECS	Contact for details

Quality Control

Every batch of Bromo-Peg5-T-Butyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and absence of critical impurities. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.