Description

Bromoacetamido-Peg5 -Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive bromoacetamide group and a terminal azide. This compound is specifically engineered for site-specific bioconjugation and the creation of stable, well-defined molecular architectures. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced materials development who require precise and reliable crosslinking strategies.

Application

• ADC (Antibody-Drug Conjugate) Development: For the controlled, site-specific attachment of cytotoxic payloads to monoclonal antibodies via the azide-alkyne cycloaddition and thiol-bromoacetamide chemistry.
• PEGylation of Biologics: To introduce a hydrophilic PEG spacer, improving the solubility, stability, and pharmacokinetic profiles of therapeutic peptides and proteins.
• Surface Functionalization: For modifying nanoparticles, biosensors, and microarray surfaces with bioorthogonal azide groups for subsequent click chemistry reactions.
• Polymer Chemistry: As a versatile building block in the synthesis of functionalized, stimuli-responsive hydrogels and block copolymers.
• Diagnostic Probe Synthesis: In the construction of fluorescent or radioactive imaging probes by conjugating targeting ligands to reporter molecules.
• Protein-Protein Crosslinking: For studying protein interactions or creating stable protein complexes through cysteine-specific alkylation.

Basic Information

Product Name	Bromoacetamido-Peg5 -Azide
CAS No.	1415800-37-1
Molecular Formula	C19H35BrN4O8
Molecular Weight	527.41 g/mol
Synonyms	1-Bromo-2,5-dioxopyrrolidin-1-yl 2,5,8,11,14-pentaoxa-17-azanonadecan-19-oate; Bromoacetamido-PEG5-azide; N-(Azido-PEG5)-bromoacetamide; Azido-PEG5-C2-Br; Bromoacetyl-PEG5-azide; 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-yl 2-bromoacetate; Heterobifunctional PEG linker, Bromoacetamide-Azide
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg5 -Azide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional group analysis to ensure consistent reactivity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Bromoacetamide)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.