Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine Hydrochloride is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in pharmaceutical research and development. Its core value lies in its dual functionality, combining a protected boronic acid ester for Suzuki-Miyaura cross-coupling reactions with a piperazine moiety that serves as a versatile pharmacophore and linker. This compound is critically needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the efficient formation of carbon-carbon bonds between aromatic systems, a cornerstone reaction in drug discovery.
• Library Synthesis for Drug Screening: Used in high-throughput and parallel synthesis to create diverse compound libraries for hit identification and lead optimization campaigns.
• Ligand and Catalyst Development: Employed in the preparation of novel piperazine-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Acts as a building block for developing new crop protection agents and herbicides.
• Material Science: Utilized in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.

Basic Information

Product Name	1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine Hydrochloride
CAS No.	1415794-62-5
Molecular Formula	C16H26BClN2O2
Molecular Weight	324.65 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine hydrochloride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylpiperazine hydrochloride; 1-(4-Pinacolatoboronphenyl)piperazine HCl; 4-(Piperazin-1-yl)phenylboronic acid pinacol ester hydrochloride; (4-(Piperazin-1-yl)phenyl)boronic acid pinacol ester hydrochloride; CAS 1415794-62-5
EINECS	Contact for details

Quality Control

Our 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. We support development and commercial projects requiring consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.