Description

2-Methyl-1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propan-2-Ol is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and materials science sectors for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Materials Science Research: Serves as a monomer or precursor for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the synthesis of molecular probes and tool compounds for target identification and validation studies.
• Cross-Coupling Reactions: A specialized reagent for palladium-catalyzed Suzuki-Miyaura couplings, enabling the efficient introduction of phenolic boronate moieties into complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Methyl-1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propan-2-Ol
CAS No.	1415793-95-1
Molecular Formula	C16H25BO4
Molecular Weight	292.18 g/mol
Synonyms	2-Methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propan-2-ol; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]-2-methylpropan-2-ol; 4-(2-Hydroxy-2-methylpropoxy)phenylboronic acid pinacol ester; Pinacol [4-(2-hydroxy-2-methylpropoxy)phenyl]boronate; 4-(2-Methyl-2-hydroxypropoxy)benzeneboronic acid pinacol ester; B-[4-(2-Hydroxy-2-methylpropoxy)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Methyl-1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Propan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.