Description

n-Boc-2-Methyl-1,4-Piperidinedicarboxylic Acid Methyl Ester is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine and carboxylic acid functionalities, enabling selective deprotection and subsequent functionalization for complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those containing substituted piperidine scaffolds.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and conformationally constrained mimetics to modulate biological activity.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with specific stereochemical requirements.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged or modified molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high stereochemical purity and reliable scalability.

Basic Information

Product Name	n-Boc-2-Methyl-1,4-Piperidinedicarboxylic Acid Methyl Ester
CAS No.	1415740-83-8
Molecular Formula	C15H25NO6
Molecular Weight	315.36 g/mol
Synonyms	1,4-Piperidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) 4-methyl ester; tert-Butyl 2-methyl-4-(methoxycarbonyl)piperidine-1-carboxylate; 1-Boc-2-methyl-4-(methoxycarbonyl)piperidine; Methyl 1-(tert-butoxycarbonyl)-2-methylpiperidine-4-carboxylate; 2-Methyl-1-Boc-piperidine-4-carboxylic acid methyl ester; Boc-2-methyl-piperidine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-2-Methyl-1,4-Piperidinedicarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong bases and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.