Description

1-Oxa-7-Azaspiro[4.5]Decane (Hydrochloride) is a bicyclic heterospiro compound featuring a fused oxazine and piperidine ring system, widely employed as a privileged scaffold in medicinal chemistry. Its structural rigidity and nitrogen/oxygen functionality enable selective modulation of biological targets, making it a high-value intermediate for the synthesis of novel CNS-active pharmaceuticals and kinase inhibitors. This compound is essential for research and development teams in global pharmaceutical CROs, API manufacturers, and academic drug discovery laboratories seeking structurally diverse, stereochemically defined building blocks.

Application

• Key synthetic intermediate for GABAA receptor modulators and anxiolytic candidates
• Core scaffold in the design of selective 5-HT6 receptor antagonists for cognitive disorder therapeutics
• Building block for spirocyclic protease inhibitors targeting viral replication (e.g., SARS-CoV-2 Mpro)
• Chiral template in asymmetric catalysis for enantioselective C–N bond formation
• Structural motif in PET radiotracer development due to favorable logP and metabolic stability
• Component in high-throughput library synthesis for hit-to-lead optimization campaigns

Basic Information

Product Name	1-Oxa-7-Azaspiro[4.5]Decane (Hydrochloride)
CAS No.	1415562-85-4
Molecular Formula	C9H16ClNO
Molecular Weight	189.68 g/mol
Synonyms	1-Oxa-7-azaspiro[4.5]decane hydrochloride; Spiro[4.5]decan-7-amine, 1-oxa-, hydrochloride; 7-Azabicyclo[2.2.2]octane, 1-oxa-7-aza-, hydrochloride; 1-Oxa-7-azaspiro[4.5]decane HCl; OASD·HCl; CAS 1415562-85-4; Hydrochloride salt of 1-oxa-7-azaspiro[4.5]decane; 7-Hydroxy-1-oxa-7-azaspiro[4.5]decane hydrochloride (misnomer – included for search coverage)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, residual solvents, heavy metals, and related substances. The material meets stringent purity requirements for pharmaceutical R&D use and is manufactured under ISO 9001-certified processes.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant during handling and reseal containers promptly after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (Karl Fischer)	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.