Description

5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable source of this specialized building block for preclinical and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential therapeutic agents, particularly for neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredient (API) manufacturing.
• Academic Research: Utilized in university and institutional labs for studying spirocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride
CAS No.	1414959-11-7
Molecular Formula	C13H13BrClNO2
Molecular Weight	330.60 g/mol
Synonyms	5-Bromospiro[isobenzofuran-1(3H),4'-piperidin]-3-one hydrochloride; 5-Bromo-3H-spiro[2-benzofuran-1,4'-piperidine]-3-one hydrochloride; 5-Bromo-3H-spiro[isobenzofuran-1,4'-piperidine]-3-one HCl; 5-Bromospiro[isobenzofuran-1(3H),4'-piperidine]-3-one hydrochloride; 1414959-11-7; Spiro[isobenzofuran-1(3H),4'-piperidine]-3-one, 5-bromo-, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Bromo-3H-Spiro[Isobenzofuran-1,4'-Piperidin]-3-One Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.