Description

n-Boc-9-Azidononan-1-Amine is a bifunctional organic building block featuring a protected amine and a terminal azide group, designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise, modular construction of complex molecules, particularly through click chemistry and peptide coupling reactions. It is primarily utilized by the pharmaceutical, bioconjugation, and materials science industries for developing targeted drug delivery systems, diagnostic probes, and functionalized polymers.

Application

• Bioconjugation and Labeling: Used as a linker to attach fluorescent dyes, biotin, or other reporter molecules to proteins, antibodies, or oligonucleotides via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Peptide and PROTAC Synthesis: Serves as a key intermediate for introducing functional spacers or polyethylene glycol (PEG) chains into peptide sequences and proteolysis-targeting chimeras (PROTACs).
• Polymer and Material Functionalization: Enables the surface modification of nanoparticles, hydrogels, and other polymeric materials to introduce amine-reactive sites or bioactive ligands.
• Chemical Biology Probes: Integral in the synthesis of activity-based probes (ABPs) and photoaffinity labels for studying enzyme function and protein-protein interactions.
• Antibody-Drug Conjugate (ADC) Development: Acts as a versatile linker component for constructing stable, cleavable connections between cytotoxic payloads and monoclonal antibodies.
• Solid-Phase Synthesis: Employed in combinatorial chemistry and library generation on resin supports for high-throughput screening of novel bioactive compounds.

Basic Information

Product Name	n-Boc-9-Azidononan-1-Amine
CAS No.	1411977-81-5
Molecular Formula	C₁₄H₂₈N₄O₂
Molecular Weight	284.40 g/mol
Synonyms	9-Azido-1-[(tert-butoxycarbonyl)amino]nonane; 1-Amino-9-azidononane Boc derivative; tert-Butyl (9-azidononyl)carbamate; N-Boc-1,9-diaminononane azide; Boc-NH-(CH₂)₉-N₃; Azido-PEG9-amine Boc protected; 9-Azidononan-1-amine, N-Boc-protected
EINECS	Contact for details

Quality Control

Our n-Boc-9-Azidononan-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring the material meets the stringent requirements for research and cGMP-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to prevent degradation. Keep away from strong oxidizing agents and sources of heat.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.