Description

tert-Butyl 3-Oxo-1-Oxa-6-Azaspiro[3.4]Octane-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic heterocycle class. This compound is a critical building block in modern medicinal chemistry, valued for its unique three-dimensional structure that enables the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in drug discovery programs, especially for probing challenging biological targets.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of heterobifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the synthesis of specialized molecular tools for studying enzyme function and cellular pathways.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of candidate drugs.

Basic Information

Product Name	tert-Butyl 3-Oxo-1-Oxa-6-Azaspiro[3.4]Octane-6-Carboxylate
CAS No.	1408076-43-6
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	6-Boc-3-oxo-1-oxa-6-azaspiro[3.4]octane; tert-Butyl 3-oxo-1-oxa-6-azaspiro[3.4]octane-6-carboxylate; 1-Oxa-6-azaspiro[3.4]octane-6-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[3.4]octan-3-one; Boc-1-oxa-6-azaspiro[3.4]octan-3-one; 1408076-43-6; 3-Oxo-1-oxa-6-azaspiro[3.4]octane-6-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Oxo-1-Oxa-6-Azaspiro[3.4]Octane-6-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.